• 1997 – Molecular epidemiology of infectious diseases, Stanford.
  • 1994 – Specialty in Infectology, INNSZ.
  • 1991 – Specialty in Internal Medicine, INNSZ.
  • 1987 – Medicine, National Autonomous University of Mexico

Academic appointments:

  • Head, Laboratory of Clinical Microbiology, National Institute of Medical Sciences and Nutrition Salvador Zubirán.
  • Researcher in Medical Sciences E, INCMNSZ.
  • National System of Researchers, Level III.
  • Advisor to the Tuberculosis Control Program in Mexico
  • Member of the STOP TB Committee in Mexico
  • Undergraduate professor at the Universidad Panamericana School of Medicine
  • Visiting professor of the Faculty of Medicine of the UNAM
  • Professor of the specialty of Infectology, masters and doctoral tutor at UNAM.

Research interests:

  • Tuberculosis.
  • Molecular Epidemiology.
  • Bacterial resistance.
  • Invasive Fungal Infections.

Featured projects: 

  • He has coordinated various research groups to study tuberculosis in conjunction with the INSP, INER, UNAM, and more than ten foreign universities and graduated  Ph.D. students in the area of ​​tuberculosis.

Selected publications

  • Rios-Muñiz D, Cerna-Cortes JF, Lopez-Saucedo C, Angeles-Morales E, Bobadilla-Del Valle M, Ponce-de Leon A, Estrada-Garcia T. Longitudinal Analysis of the Microbiological Quality of Raw Cow’s Milk Samples Collected from Three Small Family Dairy Farms in Mexico over a 2-Year Period. J Food Prot. 2019 Dec;82(12):2194-2200. doi: 10.4315/0362-028X.JFP-19-155. PubMed PMID: 31742445.
  • Guerra-De-Blas PDC, Bobadilla-Del-Valle M, Sada-Ovalle I, Estrada-García I, Torres-González P, López-Saavedra A, Guzmán-Beltrán S, Ponce-de-León A, Sifuentes-Osornio J. Simvastatin Enhances the Immune Response Against Mycobacterium tuberculosis. Front Microbiol. 2019 Sep 20;10:2097. doi:10.3389/fmicb.2019.02097. eCollection 2019. PubMed PMID: 31616387; PubMed Central PMCID: PMC6764081.
  • Lee-Tsai YL, Luna-Santiago R, Demichelis-Gómez R, Ponce-de-León A, Ochoa-Hein E, Tamez-Torres KM, Bourlon MT, Bourlon C. Determining the risk factors associated with the development of Clostridium difficile infection in patients with hematological diseases. Blood Res. 2019 Jun;54(2):120-124. doi:10.5045/br.2019.54.2.120. Epub 2019 Jun 25. PubMed PMID: 31309090; PubMed Central PMCID: PMC6614093.
  • Walker IF, Shi O, Hicks JP, Elsey H, Wei X, Menzies D, Lan Z, Falzon D, Migliori GB, Pérez-Guzmán C, Vargas MH, García-García L, Sifuentes Osornio J, Ponce-De-León A, van der Walt M, Newell JN. Analysis of loss to follow-up in 4099 multidrug-resistant pulmonary tuberculosis patients. Eur Respir J. 2019 Jul 11;54(1). pii: 1800353. doi:10.1183/13993003.00353-2018. Print 2019 Jul. PubMed PMID: 31073080.
  • Gonzalez-Lara MF, Roman-Montes CM, Diaz-Lomeli P, Rangel-Cordero A, Valenzuela MO, Ponce-de-Leon A, Sifuentes-Osornio J, Ostrosky-Zeichner L, Martinez-Gamboa A. Azole resistance and cyp51A mutation screening in Aspergillus fumigatus in Mexico. J Antimicrob Chemother. 2019 Jul 1;74(7):2047-2050. doi:10.1093/jac/dkz121. PubMed PMID: 31220262.
  • Ortiz-Brizuela E, Leal-Vega F, Cuellar-Rodríguez J, Bobadilla-Del-Valle M, Ponce-de-León A. Vaccine-derived varicella zoster infection in a kidney transplant recipient after zoster vaccine live administration. Vaccine. 2019 Jun 12;37(27):3576-3579. doi:10.1016/j.vaccine.2019.05.017. Epub 2019 May 17. PubMed PMID: 31109718.
  • Luis BAL, Díaz-Lomelí P, Gómez-Albarrán LP, Martínez-Gamboa A, Ponce-de-León A. Mycobacterium obuense Bacteremia in a Patient with Pneumonia. Emerg Infect Dis. 2019 May;25(5):1015-1016. doi: 10.3201/eid2505.180208. PubMed PMID: 31002048.
  • Tinajero CG, Bobadilla-Del Valle M, Alvarez JA, Mosqueda JL, Ponce De Leon A, Macias AE. Vancomycin-resistant Enterococcus faecium sensitivity to isopropyl alcohol before and after implementing alcohol hand rubbing in a hospital. Am J Infect Control. 2019 Apr 27. pii: S0196-6553(19)30210-X. doi: 10.1016/j.ajic.2019.03.027. [Epub ahead of print] PubMed PMID: 31036399.
  • Ortiz-Brizuela E, Rangel-Cordero A, Ponce-de-León A, Sierra-Madero J. False-positive results in the galactomannan Platelia™ Aspergillus assay with generic piperacillin/tazobactam. Rev Iberoam Micol. 2019 Jan 28. pii: S1130-1406(18)30073-1. doi: 10.1016/j.riam.2018.07.004. [Epub ahead of print]PubMed PMID: 30704831.