DR. LEONOR HUERTA


Education:

  • 2004 – Doctorate in Basic Biomedical Research
  • 1991 – Master of Chemical Sciences (Biochemistry)
  • 1987 – Bachelor in Biology

Academic appointments:

  • Full-time Associate Researcher C, Department of Immunology, Institute of Biomedical Research, UNAM.
  • National System of Researchers, Level I.

Research interests:

  • Basic research, mainly in the area of the properties of HIV-1 envelope proteins and their biological effects.
  • Fusion of cells of the immune system induced by HIV-1, the participation of autoantibodies in the inhibition of cell fusion induced by this virus and the inhibition of in vitro infection by synthetic and natural compounds.
  • Analysis of the participation of the gp41 protein in the viral tropism and the infectious capacity of swine influenza viruses in human cells.

SELECTED PUBLICATIONS

  • Inhibition of HIV-1 envelope-dependent membrane fusion by serum antilymphocyte autoantibodies is associated with low plasma viral load. Ruiz-Rivera MB, Gómez-Icazbalceta G, Vélez-Alavez M, Viveros-Rogel M, Pérez-Patrigeon S, Lamoyi E, Llorente L, Núñez-Álvarez CA, Huerta L. Immunol Lett. 2019 Jul;211:33-40.
  • Constrained peptide models from phage display libraries highlighting the cognate epitope-specific potential of the anti-HIV-1 mAb 2F5. Palacios-Rodríguez Y, Gazarian T, Huerta L, Gazarian K. Immunol Lett. 2011 Apr 30;136(1):80-9.
  • HIV-1 V3 loop crown epitope-focused mimotope selection by patient serum from random phage display libraries: implications for the epitope structural features. Gazarian KG, Palacios-Rodríguez Y, Gazarian TG, Huerta L. Mol Immunol. 2013 Jun;54(2):148-56.
  • Flow cytometry analysis of cell population dynamics and cell cycle during HIV-1 envelope-mediated formation of syncytia in vitro. Torres-Castro I, Cortés-Rubio CN, Sandoval G, Lamoyi E, Larralde C, Huerta L. In Vitro Cell Dev Biol Anim. 2014;50(5):453-63.
  • Differences in HIV-1 viral loads between male and female antiretroviral-untreated Mexican patients. Ballesteros-Zebadúa P, Villarreal C, Cocho G, Huerta L, Estrada JL. Arch Med Res. 2013 May;44(4):296-301.
  • Quantitative and phenotypic analyses of lymphocyte-monocyte heterokaryons induced by the HIV envelope proteins: Significant loss of lymphoid markers. Rivera-Toledo E, Huerta L, Larralde C, Lamoyi E. Exp Mol Pathol. 2011 Apr;90(2):157-66.
  • Decreased CD4 and wide-ranging expression of other immune receptors after HIV-envelope-mediated formation of syncytia in vitro. Rivera-Toledo E, López-Balderas N, Huerta L, Lamoyi E, Larralde C. Arch Virol. 2010 Aug;155(8):1205-16.
  • HIV-envelope-dependent cell-cell fusion: quantitative studies. Huerta L, López-Balderas N, Rivera-Toledo E, Sandoval G, Gómez-Icazbalceta G, Villarreal C, Lamoyi E, Larralde C. ScientificWorldJournal. 2009 Aug 11;9:746-63.
  • Human immunodeficiency virus envelope-dependent cell-cell fusion: a quantitative fluorescence cytometric assay. Huerta L, Lamoyi E, Báez-Saldaña A, Larralde C. Cytometry. 2002 Feb 1;47(2):100-6.
  • Discriminating in vitro cell fusion from cell aggregation by flow cytometry combined with fluorescence resonance energy transfer. Huerta L, López-Balderas N, Larralde C, Lamoyi E. J Virol Methods. 2006 Dec;138(1-2):17-23.