• 1998 – Doctorate in Medical Sciences, UNAM
  • 1988 – Specialty in Applied Epidemiology, Secretary of Health / Centers for Disease Control and Prevention
  • 1987- Master of Medical Sciences, UNAM / INCMN
  • 1983 – Specialist in Infectology, INCMN
  • 1981 – Specialist in Internal Medicine, UNAM / INCMN
  • 1978 – Medical Surgeon, UNAM

Academic appointments:

  • Current assignment: Deputy Director of Prevention and Surveillance in Infectious Diseases of the Center for Research in Infectious Diseases, National Institute of Public Health.
  • Researcher in Sciences “F” of the National Institute of Public Health; Member of the National System of Researchers level III, Member of the National Academies of Medicine and Mexican of Sciences.

Research interests:

  • Epidemiology of infectious diseases, especially (tuberculosis) TB, HIV / AIDS, nosocomial infections, vaccines, and ethical aspects in medical research.

Featured projects:

  • 2015-2018, Efficacy, safety, adherence, and cost-effectiveness of latent TB treatment in patients with DM CONACyT.
  • 2014-2015, Community Transmission of Vaccine Poliovirus 2 Following Cessation of Routine Oral Polio Vaccine, Stanford University.
  • 2010-211, Post-eradication polio vaccination strategies, the effect of routine IPV immunization on OPV, VAPP and VSPV excretion in Mexico after national vaccination days. Stanford University.
  • 2008-2011, Validation of a latent tuberculosis diagnostic test based on interferon-gamma production by T cells in children and adolescents exposed to patients with active tuberculosis.
  • 2006-2009, Evaluation of the impact of diabetes control on the transmission and development of pulmonary tuberculosis in the general population.
  • 2006-2010, Drugs for Treatment of Latent Tuberculosis Infection. Bill & Melinda Gates Foundation.


  • Analysis of loss to follow-up in 4099 multidrug-resistant pulmonary tuberculosis patients. Walker IF, Shi O, Hicks JP, Elsey H, Wei X, Menzies D, Lan Z, Falzon D, Migliori GB, Pérez-Guzmán C, Vargas MH, García-García L, Sifuentes Osornio J, Ponce-De-León A, van der Walt M, Newell JN. Eur Respir J. 2019 Jul 11;54(1).
  • Deep sequencing prompts the modification of a real-time RT-PCR for the serotype-specific detection of polioviruses. Holubar M, Sahoo MK, Huang C, Mohamed-Hadley A, Liu Y, Waggoner JJ, Troy SB, García-García L, Ferreyra-Reyes L, Maldonado Y, Pinsky BA. J Virol Methods. 2019 Feb;264:38-43.
  • Hepatitis B seroprevalence in 10-25-year-olds in Mexico – the 2012 national health and nutrition survey (ENSANUT) results. López-Gatell H, García-García L, Echániz-Avilés G, Cruz-Hervert P, Olamendi-Portugal M, Castañeda-Desales D, Sanchez-Alemán MÁ, Romero-Martínez M, DeAntonio R, Cervantes-Apolinar MY, Cortes-Alcalá R, Alpuche-Aranda C. Hum Vaccin Immunother. 2019;15(2):433-439.
  • Characterization of Household and Community Shedding and Transmission of Oral Polio Vaccine in Mexican Communities With Varying Vaccination Coverage. Altamirano J, Purington N, Behl R, Sarnquist C, Holubar M, García-García L, Ferreyra-Reyes L, Montero-Campos R, Cruz-Hervert LP, Boyle S, Modlin J, van Hoorebeke C, Leary S, Huang C, Sommer M, Ferreira-Guerrero E, Delgado-Sanchez G, Canizales-Quintero S, Díaz Ortega JL, Desai M, Maldonado YA. Clin Infect Dis. 2018 Oct 30;67(suppl_1):S4-S17.
  • Validation of a High-throughput, Multiplex, Real-time Qualitative Polymerase Chain Reaction Assay for the Detection of Sabin Oral Polio Vaccine in Environmental Samples. Altamirano J, Leary S, van Hoorebeke C, Sarnquist C, Behl R, García-García L, Ferreyra-Reyes L, Huang C, Sommer M, Maldonado Y. Clin Infect Dis. 2018 Oct 30;67(suppl_1).
  • Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients. Ahuja SD, Ashkin D, Avendano M, Banerjee R, Bauer M, Bayona JN, Becerra MC, Benedetti A, Burgos M, Centis R, Chan ED, Chiang CY, Cox H, D’Ambrosio L, DeRiemer K, Dung NH, Enarson D, Falzon D, Flanagan K, Flood J, Garcia-Garcia ML, Gandhi N, Granich RM, Hollm-Delgado MG, Holtz TH, Iseman MD, Jarlsberg LG, Keshavjee S, Kim HR, Koh WJ, Lancaster J, Lange C, de Lange WC, Leimane V, Leung CC, Li J, Menzies D, Migliori GB, Mishustin SP, Mitnick CD, Narita M, O’Riordan P, Pai M, Palmero D, Park SK, Pasvol G, Peña J, Pérez-Guzmán C, Quelapio MI, Ponce-de-Leon A, Riekstina V, Robert J, Royce S, Schaaf HS, Seung KJ, Shah L, Shim TS, Shin SS, Shiraishi Y, Sifuentes-Osornio J, Sotgiu G, Strand MJ, Tabarsi P, Tupasi TE, van Altena R, Van der Walt M, Van der Werf TS, Vargas MH, Viiklepp P, Westenhouse J, Yew WW, Yim JJ; Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB. PLoS Med. 2012;9(8).
  • [The ABCs on anthrax for health personnel]. Valdespino-Gómez JL, García-García ML. Salud Publica Mex. 2001 Nov-Dec;43(6).
  • [Mycobacterium tuberculosis in lungs without tuberculous lesions–an immunologic sanctuary?]. García-García ML, Valdespino JL. Rev Invest Clin. 2001 Sep-Oct;53(5):460-1.
  • [The 2008 Nobel Prizes in medicine and physiology]. Valdespino JL, Ponce-de-León S, de Lourdes Garcia M. Gac Med Mex. 2009 May-Jun;145(3).
  • Rifampin and pyrazinamide vs isoniazid for prevention of tuberculosis in HIV-infected persons: an international randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS, the Adult AIDS Clinical Trials Group, the Pan American Health Organization, and the Centers for Disease Control and Prevention Study Group. Gordin F, Chaisson RE, Matts JP, Miller C, de Lourdes Garcia M, Hafner R, Valdespino JL, Coberly J, Schechter M, Klukowicz AJ, Barry MA, O’Brien RJ. JAMA. 2000 Mar 15;283(11):1445-50.
  • Prevention of HIV transmission through blood and blood products: experiences in Mexico. Sepúlveda Amor J, de Lourdes García M, Domínguez Tórix JL, Valdespino Gómez JL. Bull Pan Am Health Organ. 1989;23(1-2):108-14.